*Storage: Store all reagents at 2-8 degree C; *Accession#: EAW58904.1; P39059; *NCBI Summary: This gene encodes the alpha chain of type XV collagen, a member of the FACIT collagen family (fibril-associated collagens with interrupted helices). Type XV collagen has a wide tissue distribution but the strongest expression is localized to basement membrane zones so it may function to adhere basement membranes to underlying connective tissue stroma. The proteolytically produced C-terminal fragment of type XV collagen is restin, a potentially antiangiogenic protein that is closely related to endostatin. Mouse studies have shown that collagen XV deficiency is associated with muscle and microvessel deterioration. [provided by RefSeq, May 2013]; *Uniprot Summary: Function: Structural protein that stabilizes microvessels and muscle cells, both in heart and in skeletal muscle. Ref.8Restin potently inhibits angiogenesis By similarity. Ref.8Subunit structure: Trimer; disulfide-linked. Ref.7 Ref.9Subcellular location: Secreted › extracellular space › extracellular matrix By similarity. Tissue specificity: Expressed predominantly in internal organs such as adrenal gland, pancreas and kidney.Post-translational modification: Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.O-glycosylated; with core 1 or possibly core 8 glycans. An N-terminal peptide contains chondroitin sulfate. Ref.9 Ref.10Sequence similarities: Belongs to the multiplexin collagen family.Contains 4 collagen-like domains.Contains 1 laminin G-like domain.Caution: The name restin has also been used for CAP-Gly domain-containing linker protein 1 the product of the CLIP1 gene.
