Same for Dogs 120 Tablets - Liver Supplement, Brain & Mood Support

Well, I have a research background and therefore also a heavy helping of skepticism but was willing to try something to help our 15-16 year old 40 lb rescue mutt who had been showing signs of canine cognitive dysfunction over the past several weeks, and perhaps even longer without us really noticing. She paces and pants, particularly during "sundowning" hours, and at night she would wake up, pace, pant, whine, and paw frantically at her bed while turning in circles (a "nesting" behavior that she has always had but became much more pronounced and prolonged). She also started having accidents in the house, and she has always been a 100% perfectly housetrained dog. So here are the variables I changed, all in a single day: I started giving her this pill (one pill mid-morning and one pill right before bed), started adding salmon oil to her meals (twice daily), incorporated a very short down-the-block-and-back afternoon/evening walk into her regular daily routine (she has hated walks ever since we adopted her), and made a commitment to letting her out to potty more frequently. She is in very good physical health, no signs of arthritis and has maintained good muscle mass. The very first night she slept like a baby. Insert dose of heavy skepticism here. The second night she slept like a baby. So? I remain skeptical but will update if this changes. From what I can see, this has made a very big difference already. She loves the taste of the pill and takes it readily - and she is a VERY picky dog, food-wise. It has not caused any stomach upset and she has a VERY sensitive stomach. We will see... 3-month update: She's still sleeping like a baby through the night and the panting and pacing has disappeared! We have not changed the dose (she gets 2 pills daily - one in the morning and one at night right before bed). She generally seems more alert and sprightly. She doesn't even bother chewing these anymore (they're actually a bit too hard to chew) but no matter...she takes them with gusto and swallows them whole! So glad we started her on these supplements! Almost-1-year update: Our now 16-17-year-old rescue mutt is still doing well and still taking this supplement. We have since added the milk thistle tablets by the same company (the combo of SAM-e + milk thistle are basically what's in the veterinary medicine Denamarin). Our vet agrees that giving our dog these supplements is a good idea. Interestingly, she also said that SAM-e either works like magic, or doesn't work at all. So, I hope that if you are trying this, you have a dog that falls into the "SAM-e works like magic" camp because this has definitely given back our dog's quality of life, and we are thrilled for her to still be with us. Also as a disclaimer, we did have to start our dog on Galliprant (prescription osteoarthritis medicine) as well, which is not surprising given her age, so that definitely also improves her quality of life. We will keep on trucking with our geriatric pup! Final 2020 update: We lost our wonderful girl at the end of June to potential liver and/or cardiac failure. She was probably between 16.5-17 years old. Interestingly she went downhill very quickly - it was like flipping a light switch - and we took her to the emergency vet and let her keep going down the Rainbow Bridge. I do not have lab value evidence that this product worked (we decided to skip bloodwork given our dog's age and anxiety levels at the vet, and knowing that even if we were to find evidence of liver failure, there would not be much we could do) but instead watched her clinical signs carefully. In her last weeks, she was probably uncomfortable but still enjoyed eating (very much!) and was very mobile and able to potty totally normally and rested easily at night. I am thankful that her decline was so sudden and dramatic - it made it "easier" for us to make a hard decision, and she did not suffer long. I can say with certainty that this supplement improved her quality of life and she took it for a full 12 months. Good girl, doggo. Love you forever.

I have used this for 2 of my dogs, and it has worked well for both of them - one geriatric with normal aging signs, and one young diabetic, given to prevent organ damage. Great product. Use with Milk Thistle (same brand) and this combination is the same as giving Denamarin. Not nearly as expensive, and no prescription needed.

These supplements have been a good alternative to more expensive veterinary products. We started giving them to our dog to help keep her liver enzymes stable, and they've worked very well for us. Since using them, her bloodwork has remained stable without any further decline. Another big plus is the price. They are much more affordable than the medications and liver supplements we were purchasing through our veterinarian, making them a great value. Our dog also loves the flavor. She happily eats them like a treat, so we don't have to hide them in cheese or peanut butter or wrap them in another treat to get her to take them. We have been pleased with the results over a couple of years for our dog's liver health and would recommend them.

Got this product as our 11yr old lab mix was starting to exhibit signs of canine cognitive disorder; confusion at basic commands and increased anxiety and withdrawal. So far he's showing signs of improvement. His commands are improving and his anxiety has lessened. We only give him 2 total pills a day instead of the 4 he should get by body weight. The product is kinda pricey for bigger dogs. We do have to use peanut butter to get him to eat it too, as he's not keen on the flavor on it's own. Overall a good thing to help keep our senior dog thriving.

Brought my dog into the vet for a routine dental cleaning and bloodwork. Unfortunately, when the bloodwork results came back her liver enzyme levels were four times what they should be. My vet recommended trying a liver supplement, putting her on Denamarin (which is essentially a vet backed/prescribed liver supplement), and/or taking her to a specialist to get an ultrasound of her liver and kidneys done. I called the specialist to get a quote for how much the ultrasound would be and was unable to afford it, so I looked for the next best thing. I researched the ingredients and differences between Denamarin and over the counter liver supplements to try for her and found these Coco and Luna chewable tabs. The Coco and Luna supplements (S-Adenosyl-L-Methionine + Milk Thistle) are much more affordable for me than Denamarin and work just as well. My baby girl is not super picky when it comes to treats and so she takes these with ease, but loves them! She actually starts drooling haha when I am opening up the jars to pour them out for her, she loves their taste so much! I took my girl back into the vet today to recheck her bloodwork and the vet says her liver values have gone down substantially and are back within normal ranges. (As I type this, I have only been giving her these supplements for a month and a half). NOTE: My girl is 75lbs and I give her two tabs of the S-Adenosyl-L-Methionine and two tabs of the Milk Thistle once a day in the mornings = total 4 tablets per day) and they have helped her tremendously. Based on the dosages I have been giving her, these two bottles will last me two months. Thank you again! I can't say enough how appreciative I am for companies like Coco and Luna for manufacturing affordable pet care products.

My furbaby had very high liver enzymes. My vet suggested these. I give him two a day with milk thistle and it has brought his numbers way down and they continue to improve. They work well! They are a little big for him and he doesn't like to chew hard stuff so, i chop them up and add them to his food. He doesn't get sick in the middle of the night anymore and sleeps through the night again.

My 15 pound Jack Russell/Chihuahua had been on Denosyl since April 2025, she took milk thistle too but her ALT number slowly climbed from 319 in 4/2025 to 544 in 3/2026... she is completely asymptomatic and the liver ultrasound showed no abnormalities. In March I started her on half a Trazodone every morning to help with her separation anxiety which caused great stress (and I believe contributed to an elevated ALT.) On June 24, 2026 I switched her from Denosyl to this SAMe, she gets 2 chewable tablets a day which is actually half the milligrams of Denosyl.. she had blood work this morning, her ALT is 301!! Needless to say Coco & Luna SAMe & Milk Thistle plus half a Trazodone seems to be the magic recipe for my sweet girl.

My dog hated the smell and taste. And there is something really wrong with this product. My dog was rec to take this due to elevated liver enzymes most likely due to poisoning of pesticides sprayed on grass at our housing. After taking this product he started experiencing jaundice and his liver enzymes and billirubin were higher than before. The vet told me to bump up the dose so he was getting the correct amount for his size. She said suppliments wouldn't hurt. 2 weeks later the jaudice,lack of appetite, fatigue had worsened. He appeared to be in pain based on sounds he was making. He ended up HOSPITALIZED and on fluids. Upon further research, I found that the L in sameLq is licorice root extract. Not good for dogs at all. Also there is limited research of Same efficacy and safety for dogs. There was a study done on humans and rats showing that same when digested breaks down into toxins that can be extremely damaging to the liver and other organs. They have not been able to determine what a safe dose would be, if any. My baby seems more stable after stopping the samelq. We are still waiting on test results to figure out the prognosis.