Solitude IGR is a feed-through fly preventive which, when mixed 1 to 2 oz into a horses ration daily according to the directions, will prevent house and stable fly development. Cyromazine, the active ingredient in Solitude IGR, is an insect growth regulator that works on the flys chitin exoskeleton and is very species specific to house and stable flies. As the horse is fed cyromazine in Solitude IGR, it passes through the horse and is excreted in the manure. House flies and stable flies lay their eggs in the manure and the eggs subsequently hatch into the larval or maggot stage. (Cyromazine has no effect on the chitin of the adult fly.) As the maturing maggots feed on the manure treated with cyromazine, they become unable to successfully develop into adult flies because cyromazine inhibits the proper formation of chitin. The immature stage of the fly dies. Cyromazine has a well documented safety and efficacy profile. It has been extensively evaluated in horses since 2001 as well as intensely studied in other species for more than 20 years. Numerous environmental studies have documented cyromazines safety for mammals including humans and horses, as well as birds, daphnia, minnows and other indicator species. Once excreted, Solitude IGR breaks down to a melamine monomer, a slow release nitrogen fertilizer.
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