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Over the last century, thousands of people have gone missing. Suddenly and inexplicably, 4400 missing people are returned, all at once, exactly as they were on the day they vanished. Unclear what this world-altering event means, the government investigates the 4400 to piece together where they've been and why they've been returned. It quickly becomes apparent that their presence will change the human race in ways no one could have foreseen. .com ---- There's nothing like a psych-out to shake things up. In The 4400's fourth season opener, everyone has taken the medicine Jordan Collier (Billy Campbell) distributed in year three, and all's right with the world. Then he wakes up from his dream. In truth, promicin helps some and harms others. Soon, Shawn (Patrick Flueger) emerges from his coma and Isabelle (Megalyn Echikunwoke), who tried to kill him, escapes from prison. As for NTAC, agents Tom (Joel Gretsch) still mourns the missing Alana, while Diana (Jacqueline McKenzie) returns to work when she finds out her sister, April (Natasha Gregson Wagner), has taken the . As the season continues, promicin-related strangeness accelerates, like the outcast (Cameron Bright) who becomes a messiah--and insists his followers only listen to TV on the radio--or the librarian (Constance Towers) who can astral project. An attractive new NTAC supervisor, Meghan Doyle (Jenni Baird), joins Tom and Diana to monitor the positives and those they affect, including Tom's son, Kyle (Chad Faust), who helps Collier establish Seattle's Promise City, an all-positive community. As ever, shades of grey dominate, and anyone can change at any time. Even an NTAC agent can become one of the Marked. The fourth year ends with a viral outbreak, followed by the death of a key character. For the most part, though, the conclusion holds out hope for relations between the positives and the rest of the population--if they can stop the Marked in time. Because the USA Network chose not to renew the show, some questions may never be answered. Fortunately, The 4400 went out with both humor and heart. Extra features include deleted scenes, featurettes, a blooper reel, and commentary from creator Scott Peters on "Till We Have Built Jerusalem" and the director's cut of finalé "The Great Leap Forward." --Kathleen C. Fennessy